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1.
Sustainability ; 15(10), 2023.
Article in English | Web of Science | ID: covidwho-20245335

ABSTRACT

Businesses have been exposed to various challenges during the global pandemic. Unfortunately, the financially vulnerable groups in society are disproportionately affected by such a difficult time. Therefore, it is important for businesses to recognise this when creating new business models for sustainable corporate management. This paper attempts to (1) identify the factors that affect individual financial vulnerability, (2) develop survey items to assess financial vulnerability and its factors and (3) provide the characteristics of financially vulnerable groups by presenting a complete set of descriptive statistics. The results can help to create more inclusive business models that are better equipped to address the challenges ahead. A questionnaire-based survey was conducted with collaboration with an NGO that provides a financial counselling service in Hong Kong. In total, 338 valid responses were collected and the data were used to characterise financially vulnerable groups in terms of (1) change in financial conditions due to COVID-19;(2) exposure to digitised financial services and related push marketing;(3) financial management ability;(4) changes in four financial behaviours and (5) financial vulnerability as measured according to the debt/service ratio. Results show that the respondents have a median debt/service ratio of 0.513, which represents an unsustainable level of debt. Around 1/4 of surveyed respondents reported that their debt/service ratio was 1 or even higher, indicating obvious difficulties in meeting financial obligations. A total of 36.7% of the respondents reported worsening financial conditions since the outbreak of COVID-19. The results presented provide a solid empirical set of data that will help future research work to examine and/or develop a heuristic financial vulnerability model that incorporates the key factors leading to it. Businesses can refer to them when creating new business models that are sustainable, able to meet corporate social responsibility goals and can achieve several targets/goals of the United Nations' Sustainable Development Goals.

2.
Natural Product Communications ; 18(4), 2023.
Article in English | EMBASE | ID: covidwho-2316742

ABSTRACT

Background: Viral infections pose some of the most serious human health concerns worldwide. The infections caused by several viruses, including coronavirus, hepatitis virus, and human immunodeficiency virus, are difficult to treat. Method(s): This review details the findings of a literature search performed on the antiviral properties of luteolin. The keywords engaged in the search are "virus" along with "luteolin." Results: Luteolin possesses antiviral properties, which is the basis for the current review. It is an important natural flavonoid with numerous important biological properties, including anti-inflammatory, immune regulatory, and antitumor effects, and is found in vegetables, fruits, and several medicinal plants. Recent studies have revealed that many traditional Chinese medicines that contain luteolin inhibit the replication of coronaviruses. Conclusion(s): Luteolin effectively inhibits the replication of coronavirus, influenza virus, enterovirus, rotavirus, herpes virus, and respiratory syncytial virus, among others. In particular, it prevents viral infection by improving the body's nonspecific immunity and antioxidation capacity and inhibiting many pathways related to virus infection and replication, such as MAPK, PI3K-AKT, TLR4/8, NF-kappaB, Nrf-2/hemeoxygenase-1, and others. It also regulates the expression of some receptors and factors, including hepatocyte nuclear factor 4alpha, p53, NLRP3, TNF-alpha, and interleukins, thereby interfering with the replication of viruses in cells. Luteolin also promotes the repair of damaged cells induced by proinflammatory factors by regulating the expression of inflammatory molecules. The overall effect of these processes is the reduction in viral replication and, consequently, the viral load. This review summarizes the antiviral effect of luteolin and the mechanism underlying this property.Copyright © The Author(s) 2023.

3.
Biocell ; 47(2):367-371, 2023.
Article in English | Web of Science | ID: covidwho-2311552

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of the ongoing coronavirusdisease 2019 (COVID-19) global pandemic. Here, by centralizing published cell-based experiments, clinical trials, andvirtual drug screening data from the NCBI PubMed database, we developed a database of SARS-CoV-2 inhibitors forCOVID-19, dbSCI, which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-basedexperiments, 81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformaticsanalyses. dbSCI provides four major functions: (1) search the drug target or its inhibitor for SARS-CoV-2, (2) browsetarget/inhibitor information collected from cell experiments, clinical trials, and virtual drug screenings, (3) download,and (4) submit data. Each entry in dbSCI contains 18 types of information, including inhibitor/drug name, targetingprotein, mechanism of inhibition, experimental technique, experimental sample type, and reference information. Insummary, dbSCI provides a relatively comprehensive, credible repository for inhibitors/drugs against SARS-CoV-2and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19

4.
British Journal of Educational Technology ; 2023.
Article in English | Scopus | ID: covidwho-2306064

ABSTRACT

The necessity for the development and enhancement of teacher commitment to satisfying students' learning needs in response to the COVID crisis is increasingly highlighted. It is not known, however, how to increase commitment in schoolteachers to boost online teaching in light of the fact that they, too, are struggling to cope with the rapid, unexpected change. A total of 601 teachers from primary and secondary schools across China participated in this study, with an average teaching experience of 15.9 years. Structural equation modelling was used to verify the significance of contextual, cognitive, affective and behavioural factors in boosting teachers' commitment to online teaching. The findings demonstrated that teacher agency played a complete mediating role in the predicting power of other factors to teacher commitment. Therefore, it was recommended that attention be paid to the practice and opportunities for teacher agentic actions, which necessitates real encounters with online teaching, allowing teachers to act meaningfully and initiate a new set of teaching strategies. Practitioner notes What is already known about this topic The large-scale transition to emergency online teaching serves as the catalyst for creating a blended or hybrid model of education provision in the long term. How hard teachers work to perform at their best and overcome obstacles to support students' learning needs in new environment relies on the intensity of teacher commitment to change. Online and blended learning requires teachers to not only be prepared for a diverse learning environment but also to build and rebuild their own identity as future teachers. What this paper adds This study adds to our knowledge of how traditional F2F classroom teachers reinvented their roles and responsibilities in response to the pandemic-driven challenges based on real-world experiences. As a result of the COVID-19 lockdown school closures, schoolteachers' commitment to enhancing online teaching efforts has increased. The study highlights the complete mediating role of teacher agency in the predicting power of cognitive and affective factors to teacher commitment. Implications for practice and/or policy To learn more about how to be a good online teacher, future teachers need greater deliberate effort in diverse online teaching activities. Future teachers should be equipped with not only new technological and remote instructional strategies and skills, but also with confidence in, value for, and actual experiences with online teaching in a technology-rich environment. For teachers to obtain hands-on experience in integrating technology with distance teaching pedagogy at a time of rapid change, schools should have some days online and offer blended learning opportunities wherever possible. © 2023 British Educational Research Association.

5.
Chinese Journal of Diabetes Mellitus ; 12(7):500-503, 2020.
Article in Chinese | EMBASE | ID: covidwho-2306020

ABSTRACT

Objective: To investigate the blood glucose control of diabetic patients during the Coronavirus disease 2019 (COVID-19) epidemic, and to explore the factors affecting blood glucose. Method(s): Three hundred and fifty patients with diabetes mellitus hospitalized in the Endocrinology Department of the Second Affiliated Hospital of Air Force Military Medical University from 2017 to 2019 were selected, and we send questionnaires (a self-made questionnaire containing 39 questions, Zung anxiety self-assessment scale, Zung depression self-assessment scale) to the patients through WeChat group. After the effective questionnaires were collected, the patients were divided into good blood glucose control group (fasting blood glucose <=7 mmol/L and 2 h postprandial blood glucose <=10 mmol/L) and poor blood glucose control group (fasting blood glucose>7 mmol/L and/or 2 hours postprandial blood glucose>10 mmol/L). Chi square test or Fisher exact probability method and t test were used to compare the differences between the two groups. In Multi-factor logistic regression, the backward regression method was performed. Result(s): A total of 310 questionnaires were collected, 4 of which did not meet the requirements were eliminated, and a total of 306 valid questionnaires were analyzed. There were 108 cases (35.3%) in the well-controlled group and 198 cases (64.7%) in the poorly controlled group. Compared with well-controlled group, there was a higher percentage of patients with aged >=45 years, diabetes course >=5 years, combined with chronic complications of diabetes, weekly exercise time during the epidemic period<150 min,weekly monitoring of blood glucose frequency <=1 to 2 times and sleep disorders during the epidemic, anxiety, and depression in poorly controlled group, and there were statistically significant differences (P<0.05).The above 8 factors with P<0.05 were included in the logistic regression model. Diabetes course >=5 years, weekly exercise time during the epidemic<150 min, sleep disturbance during the epidemic, weekly monitoring of blood glucose frequency <= 1 to 2 times, depression were risk factors for poor blood glucose control (P<0.05). Conclusion(s): During the epidemic period, the blood glucose level of diabetes patients was generally high. The factors that affected blood glucose control included a long course of diabetes, short exercise time, low monitoring frequency of blood glucose, sleep disorders, and depression.Copyright © 2020 by the Chinese Medical Association.

6.
Chinese Journal of Digestive Surgery ; 19(3):262-266, 2020.
Article in Chinese | EMBASE | ID: covidwho-2254548

ABSTRACT

Objective: To investigate the emergency surgical strategies for patients with acute abdomen during the Corona Virus Disease 2019 (COVID-19) outbreak. Method(s): The retrospective and descriptive study was conducted. The clinical data of 20 patients with acute abdomen who were admitted to the Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology between January 18, 2020 and February 10, 2020 were collected. There were 13 males and 7 females, aged from 25 to 82 years, with an average age of 57 years. All the patients with emergency surgeries received pulmonary computed tomography (CT) examination before surgery, and completed nucleic acid detection in throat swab if necessary. Patients excluded from COVID-19 underwent regular anesthesia, suspected and confirmed cases were selected a proper anesthesia based on their medical condition and surgical procedure. Patients excluded from COVID-19 underwent emergency surgeries following the regular procedure, suspected and confirmed cases underwent emergency surgeries following the three-grade protection. Observation indicators: (1) surgical situations;(2) postoperative situations. Measurement data with normal distribution were represented as average (range). Count data were described as absolute numbers. Result(s): (1) Surgical situations: of the 20 patients with acute abdomen, 16 patients were excluded from COVID-19, and 4 were not excluded. All the 20 patients underwent emergency abdominal surgeries successfully, of whom 2 received surgeries under epidural anesthesia (including 1 with open appendectomy, 1 with open repair of duodenal bulbar perforation), 18 received surgeries under general anesthesia (including 9 with laparoscopic repair of duodenal bulbar perforation, 3 with open partial enterectomy, 3 with laparoscopic appendectomy, 1 with laparoscopic left hemicolectomy, 1 with laparoscopic right hemicolectomy, 1 with cholecystostomy). The operation time of patients was 32-194 minutes, with an average time of 85 minutes. The volume of intraoperative blood loss was 50-400 mL, with an average volume of 68 mL. (2) Postoperative situations: 16 patients excluded from COVID-19 preopratively were treated in the private general ward postoperatively. One of the 16 patients had fever at the postoperative 5th day and was highly suspected of COVID-19 after an emergency follow-up of pulmonary CT showing multiple ground-glass changes in the lungs. The patient was promptly transferred to the isolation ward for treatment, and results of nucleic acid detection in throat swab showed double positive. Medical history described by the patient showed that the patient and family members were residents of Wuhan who were not isolated at home during the epidemic. There was no way to confirm whether they had a history of exposure to patients with COVID-19. Medical staffs involved in this case did not show COVID-19 related symptoms during 14 days of medical observation. The other 15 patients recovered well postoperatively. The 4 patients who were not excluded from COVID-19 preoperatively based on medical history and results of pulmonary CT examination were directly transferred to the isolation ward for treatment postoperatively. They were excluded from COVID-19 for two consecutive negative results of nucleic acid detection in the throat swab and recovered well. Two of the 20 patients with acute abdomen had postoperative complications. One had surgical incision infection and recovered after secondary closure following opening incision, sterilizing and dressing, the other one had intestinal leakage and was improved after conservative treatment by abdominal drainage. There was no death in the 20 patients with acute abdomen. Conclusion(s): Patients with acute abdomen need to be screened through emergency forward. Patients excluded from COVID-19 undergo emergency surgeries following the regular procedure, and patients not excluded from COVID-19 undergo emergency surgeries following the three-grade protection. The temperature, blood routine test and other l boratory examinations are performed to monitor patients after operation, and the pulmonary CT and throat nucleic acid tests should be conducted if necessary. Patients excluded from COVID-19 preopratively are treated in the private general ward postoperatively, and they should be promptly transferred to the isolation ward for treatment after being confirmed. Patients who are not excluded from COVID-19 preoperatively based on medical history should be directly transferred to the isolation ward for treatment postoperatively.Copyright © 2020 by the Chinese Medical Association.

7.
Chinese Journal of Digestive Surgery ; 19(3):262-266, 2020.
Article in Chinese | EMBASE | ID: covidwho-2254547

ABSTRACT

Objective: To investigate the emergency surgical strategies for patients with acute abdomen during the Corona Virus Disease 2019 (COVID-19) outbreak. Method(s): The retrospective and descriptive study was conducted. The clinical data of 20 patients with acute abdomen who were admitted to the Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology between January 18, 2020 and February 10, 2020 were collected. There were 13 males and 7 females, aged from 25 to 82 years, with an average age of 57 years. All the patients with emergency surgeries received pulmonary computed tomography (CT) examination before surgery, and completed nucleic acid detection in throat swab if necessary. Patients excluded from COVID-19 underwent regular anesthesia, suspected and confirmed cases were selected a proper anesthesia based on their medical condition and surgical procedure. Patients excluded from COVID-19 underwent emergency surgeries following the regular procedure, suspected and confirmed cases underwent emergency surgeries following the three-grade protection. Observation indicators: (1) surgical situations;(2) postoperative situations. Measurement data with normal distribution were represented as average (range). Count data were described as absolute numbers. Result(s): (1) Surgical situations: of the 20 patients with acute abdomen, 16 patients were excluded from COVID-19, and 4 were not excluded. All the 20 patients underwent emergency abdominal surgeries successfully, of whom 2 received surgeries under epidural anesthesia (including 1 with open appendectomy, 1 with open repair of duodenal bulbar perforation), 18 received surgeries under general anesthesia (including 9 with laparoscopic repair of duodenal bulbar perforation, 3 with open partial enterectomy, 3 with laparoscopic appendectomy, 1 with laparoscopic left hemicolectomy, 1 with laparoscopic right hemicolectomy, 1 with cholecystostomy). The operation time of patients was 32-194 minutes, with an average time of 85 minutes. The volume of intraoperative blood loss was 50-400 mL, with an average volume of 68 mL. (2) Postoperative situations: 16 patients excluded from COVID-19 preopratively were treated in the private general ward postoperatively. One of the 16 patients had fever at the postoperative 5th day and was highly suspected of COVID-19 after an emergency follow-up of pulmonary CT showing multiple ground-glass changes in the lungs. The patient was promptly transferred to the isolation ward for treatment, and results of nucleic acid detection in throat swab showed double positive. Medical history described by the patient showed that the patient and family members were residents of Wuhan who were not isolated at home during the epidemic. There was no way to confirm whether they had a history of exposure to patients with COVID-19. Medical staffs involved in this case did not show COVID-19 related symptoms during 14 days of medical observation. The other 15 patients recovered well postoperatively. The 4 patients who were not excluded from COVID-19 preoperatively based on medical history and results of pulmonary CT examination were directly transferred to the isolation ward for treatment postoperatively. They were excluded from COVID-19 for two consecutive negative results of nucleic acid detection in the throat swab and recovered well. Two of the 20 patients with acute abdomen had postoperative complications. One had surgical incision infection and recovered after secondary closure following opening incision, sterilizing and dressing, the other one had intestinal leakage and was improved after conservative treatment by abdominal drainage. There was no death in the 20 patients with acute abdomen. Conclusion(s): Patients with acute abdomen need to be screened through emergency forward. Patients excluded from COVID-19 undergo emergency surgeries following the regular procedure, and patients not excluded from COVID-19 undergo emergency surgeries following the three-grade protection. The temperature, blood routine test and other l boratory examinations are performed to monitor patients after operation, and the pulmonary CT and throat nucleic acid tests should be conducted if necessary. Patients excluded from COVID-19 preopratively are treated in the private general ward postoperatively, and they should be promptly transferred to the isolation ward for treatment after being confirmed. Patients who are not excluded from COVID-19 preoperatively based on medical history should be directly transferred to the isolation ward for treatment postoperatively.Copyright © 2020 by the Chinese Medical Association.

8.
International Journal of Management Education ; 21(2), 2023.
Article in English | Scopus | ID: covidwho-2289041

ABSTRACT

Although COVID-19 is far away, the impact of the pandemic on the management of higher education remains. Within the field of entrepreneurship education research, the influence of institutional management on teacher entrepreneurship competency (TEC) has attracted more attention as they are considered one of the key engines of economic recovery. Using quantitative research as well as SEM, a total of 1241 entrepreneurship education faculty members at China's double first-class universities were surveyed using a questionnaire. The results suggest that entrepreneurship group management (EGM) and mechanism protection (EMP) in institutions have a positive predictive effect on TEC, while a partial mediating effect exists after considering teacher entrepreneurial behaviours (TEB) (including Teacher's behaviour of innovation and autonomy (BIA) and resource seeking and management (BSM)). Overall, the management of entrepreneurship education in Chinese universities has a good effect on the development of TEC. Thus, the application of tripartite interaction theory in entrepreneurship education institutions provides a good reference for the personal sustainable development of entrepreneurship teachers. The significance of institutional management for teachers should shift from the traditional provision of work to professional development and growth. © 2023 The Authors

9.
China's e-Science Blue Book 2020 ; : 15-42, 2021.
Article in English | Scopus | ID: covidwho-2288744

ABSTRACT

This forward-looking reviewfocuses on the development and applications for Biomedicine Big Data (BMBD), and its role in the engineering system for data management, scientific and technological research and development, as well as in social and economic transformation. The review starts with an elaboration on the complex connotations of BMDB from the inter-disciplinary point of view. It then explores the implications of BMDB in sectors such as life science research, medical and health institutions, and biotechnology and bio-medicine industries in connection with the challenges and opportunities faced by social and economic development. The recent COVID-19 outbreak is used as an illustrative case study. The review ends with an analysis of a decade of BMBD practice, both domestically and abroad, with suggestions for policy-making and solutions to tacklemajor challenges from China's perspective. It is hoped that anyBMBD-related institutions, including administrative, academic, industrial, financial and social organizations, practitioners and users will benefit from this insightful summary drawn from the past decades ofBMBDpractice. Any critical comments and constructive suggestions are sincerely welcomed by the authors. © Publishing House of Electronics Industry 2021.

10.
Chinese Journal of Diabetes Mellitus ; 12(7):500-503, 2020.
Article in Chinese | EMBASE | ID: covidwho-2287470

ABSTRACT

Objective: To investigate the blood glucose control of diabetic patients during the Coronavirus disease 2019 (COVID-19) epidemic, and to explore the factors affecting blood glucose. Method(s): Three hundred and fifty patients with diabetes mellitus hospitalized in the Endocrinology Department of the Second Affiliated Hospital of Air Force Military Medical University from 2017 to 2019 were selected, and we send questionnaires (a self-made questionnaire containing 39 questions, Zung anxiety self-assessment scale, Zung depression self-assessment scale) to the patients through WeChat group. After the effective questionnaires were collected, the patients were divided into good blood glucose control group (fasting blood glucose <=7 mmol/L and 2 h postprandial blood glucose <=10 mmol/L) and poor blood glucose control group (fasting blood glucose>7 mmol/L and/or 2 hours postprandial blood glucose>10 mmol/L). Chi square test or Fisher exact probability method and t test were used to compare the differences between the two groups. In Multi-factor logistic regression, the backward regression method was performed. Result(s): A total of 310 questionnaires were collected, 4 of which did not meet the requirements were eliminated, and a total of 306 valid questionnaires were analyzed. There were 108 cases (35.3%) in the well-controlled group and 198 cases (64.7%) in the poorly controlled group. Compared with well-controlled group, there was a higher percentage of patients with aged >=45 years, diabetes course >=5 years, combined with chronic complications of diabetes, weekly exercise time during the epidemic period<150 min,weekly monitoring of blood glucose frequency <=1 to 2 times and sleep disorders during the epidemic, anxiety, and depression in poorly controlled group, and there were statistically significant differences (P<0.05).The above 8 factors with P<0.05 were included in the logistic regression model. Diabetes course >=5 years, weekly exercise time during the epidemic<150 min, sleep disturbance during the epidemic, weekly monitoring of blood glucose frequency <= 1 to 2 times, depression were risk factors for poor blood glucose control (P<0.05). Conclusion(s): During the epidemic period, the blood glucose level of diabetes patients was generally high. The factors that affected blood glucose control included a long course of diabetes, short exercise time, low monitoring frequency of blood glucose, sleep disorders, and depression.Copyright © 2020 by the Chinese Medical Association.

11.
Asia-Pacific Education Researcher ; 2023.
Article in English | Scopus | ID: covidwho-2286117

ABSTRACT

Colleges and universities worldwide have adopted online teaching for short or long periods in response to the COVID-19 outbreak. This study examines the appraisal results of specific techno-stressors related to online instruction and how these appraisal results impact teachers' continuance intention towards online instruction. The investigation is important because it enables university administrators to manage different techno-stressors distinctively and adopt appropriate coping strategies to support online teaching. A research model is developed based on the transactional theory of stress (TTS) and tested empirically with a sample of 201 university teachers in China. The results reveal that (a) work overload is positively associated with university teachers' challenge appraisal but negatively associated with their threat appraisal;(b) invasion of privacy is not significantly associated with challenge or threat appraisal;(c) work–home conflict is positively associated with threat appraisal but negatively associated with challenge appraisal;and (d) challenge appraisal is positively associated with continuance intention, while threat appraisal is negatively associated with continuance intention. Implications for online learning during pandemics are discussed. © 2023, De La Salle University.

12.
International Review of Economics and Finance ; 85:473-487, 2023.
Article in English | Scopus | ID: covidwho-2281129

ABSTRACT

During the COVID-19 pandemic, stock markets were fragile and sensitive to downside news regardless of whether the news was true. In China, stock rumours are increasingly rampant, affecting the sound development of the capital market. By manually gathering a sample of rumours about Chinese A-share firms, this paper studies the effects of stock market rumours and the corresponding rumour clarifications on stock returns. The study suggests that rumours rely on the information environment to persuade the market through the media effect. In terms of information disclosure, for firms that previously disclosed "negative news”, stock prices would experience abnormal drops when negative rumours appear. In terms of the media effect, rumours released by leading media cause even more significant abnormal fluctuations in stock prices. Further study shows that positive rumours significantly cause an abnormal rise in state-owned enterprises' stock prices, while negative rumours significantly cause an abnormal decline in small and medium enterprise board (SME) and growth enterprise market board (GEM) stock prices. From the perspective of the effect of clarification announcements in restraining stock price fluctuations, clear and timely clarifications are recommended. © 2023 Elsevier Inc.

13.
7th International Conference on Electromechanical Control Technology and Transportation, ICECTT 2022 ; 12302, 2022.
Article in English | Scopus | ID: covidwho-2193329

ABSTRACT

First, this paper analyzes the congestion of container ports at home and abroad under the current epidemic situation, then takes Yantian port of Shenzhen as the key research object to analyze the waiting time at anchorage and the stopping time at berth of the main container ports in China based on the data statistics. It studies the anchorage demand of ships with random and fluctuating arrival based on queuing theory. It gives the relationship between the stopping time of ship at berth and the maximum waiting time of the arriving ship, and reveals that the increase of ship stopping time and uneven arrival at the port are the main factors causing the current container port congestion, and puts forward some countermeasures to alleviate the port congestion. © 2022 SPIE

14.
Transgenic Research ; 31(SUPPL 1):24-24, 2022.
Article in English | Web of Science | ID: covidwho-2168642
15.
Chinese Pharmacological Bulletin ; 38(5):669-675, 2022.
Article in Chinese | EMBASE | ID: covidwho-2115466

ABSTRACT

Aim To investigate the inhibitory effect of copper gluconate and disulfiran on the PLpro of SARS-CoV-2 and to explore the effect of combination of them on PLpro.Methods SARS-CoV-2 PLpro was purified by recombinant expression technology of he effects of copper gluconate and disulfiram on PLpro activity were studied by enzyme kinetic method.Results Copper gluconate and disulfiram had high inhibitory activity on SARS-CoV-2 PLpro,Ubiquitin-7-Amino-4-methylcoumarin(Ub-AMC)was used as the fluorescent substrate.The IC50 of copper gluconate was 33.02 nmol.L-1,showing competitive inhibition,and the IC50 of disulfiram was 480.4 nmol.L-1,showing non competitive inhibition,and the combination of the two inhibitors showed the advantage of synergistic inhibition.Conclusions Copper gluconate and disulfiram have a high inhibitory effect on SARS-CoV-2 PLpro protein,and the combination shows the advantage of synergistic inhibition. Copyright © 2022 Publication Centre of Anhui Medical University. All rights reserved.

16.
Neurology Perspectives ; 2(1):9-20, 2022.
Article in English, Spanish | Scopus | ID: covidwho-1959889

ABSTRACT

Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the disease COVID-19, has caused a pandemic that has rapidly affected the whole world and caused a significant threat to public health. The aim of this study was to investigate and analyze the social and occupational effects of the COVID-19 pandemic on patients with multiple sclerosis (MS) in three different countries: China, Spain, and Cuba. Methods: A cross-sectional survey was designed to assess the social and occupational effects of the COVID-19 pandemic in MS patients in these three countries, using a 25-item anonymous online questionnaire, structured into three sections. Quantitative data are expressed as mean (standard deviation), and quantitative data as absolute frequency and percentage. Results: A total of 361 participants responded to the questionnaire: 194 from China, 104 from Spain, and 63 from Cuba. We found no cases of COVID-19 among Chinese patients with MS, and few cases in Spain and Cuba. Respondents reported different levels of impact on relationships with friends, family, and colleagues, and patients in all three countries described increased use of digital or social media platforms. Spanish patients reported a significantly less negative impact than those in Cuba and China. Mental and cognitive effects were similar in all three countries, although China seemed to have a better situation. We also found that the time spent exercising decreased at specific points during the pandemic, but with few changes in dietary habits. Patients reported little or no change in their means of transport in all three countries. Most patients in all three countries reported little or no physical deterioration, especially in Chinese patients (82.47%), compared to the Spanish (70.20%) and Cuban respondents (73.02%). In general, patients from all three countries demonstrated confidence in overcoming the COVID-19 pandemic, although to a lesser extent among Spanish respondents. Conclusions: During the pandemic, family support was more effective in China than in Cuba and Spain. Neither COVID-19 infections nor the number of MS relapses increased significantly during lockdown in any of the three countries. Regarding their economic situation, Spanish MS patients reported a significantly less severe negative impact than those in Cuba and China. Patients from all three countries used digital or social media platforms more frequently, probably to maintain personal relationships. Chinese and Cuban respondents were more confident of the control of the pandemic than the Spanish, who were more pessimistic. © 2021

17.
JOURNAL OF HOSPITALITY AND TOURISM MANAGEMENT ; 51, 2022.
Article in English | Web of Science | ID: covidwho-1936785

ABSTRACT

This study aims to explore Chinese residents' outbound travel intentions and preparations in the post-pandemic world that are influenced by media coverage and risk perception. A conceptual model is proposed to test the structural relationships among media coverage, risk perception, outbound travel intentions and preparations. This study administered an online survey to Chinese residents who had outbound travel experiences, and a total of 441 valid responses were collected for data analysis. The results indicated that media coverage exerted significant impact on cognitive and affective risk perceptions, outbound travel intentions and preparations. Furthermore, cognitive risk perception was positively related to affective risk perception, which significantly influenced outbound travel intentions and preparations. Outbound travel intentions were verified as the determinant of outbound travel preparations. Additionally, the mediating roles of affective risk perception and outbound travel intentions were confirmed. This study is amongst the first to introduce the concept of outbound travel preparations as a new research avenue for post-pandemic outbound travel behaviour.

18.
Ieee Transactions on Engineering Management ; : 13, 2021.
Article in English | Web of Science | ID: covidwho-1583754

ABSTRACT

In the big data era, managing data-driven hospital operations have become one of the most important tasks for healthcare executives, increasing responsiveness to exceptional disruptions such as those caused by the COVID-19 pandemic. However, they are still facing the challenges of how best to orchestrate the digital medical resources for improving operational performance such as cost, delivery, and quality. Therefore, drawing upon resource orchestration theory, this article investigates how hospitals orchestrate data-driven culture (DDC) and digital technology orientation (DTO) to develop big data analytics capability (BDAC) for operational performance improvement. Survey data were collected from 105 hospitals in China and analyzed using structural equation modeling and ordinary least square regression. The results show that DDC has a significant positive impact on DTO. More interestingly, there is no significant interaction effect between DDC and DTO, indicating that DDC and DTO affect BDAC independently, and not synergistically. The results further reveal that BDAC fully mediates the DTO-operational performance relationship. The findings offer useful and timely guidance on how healthcare executives can manage data-driven hospital operations to improve operational performance during and post the COVID-19 pandemic.

19.
Journal of Knowledge Management ; ahead-of-print(ahead-of-print):11, 2021.
Article in English | Web of Science | ID: covidwho-1345817

ABSTRACT

Purpose This study aims to answer the question of how business models (BMs) maintain stability while coping with environmental uncertainties. This study proposes a dynamic co-evolution of knowledge management and business model transformation based on a comparative analysis of the focal firms' BMs and their main partners in two e-commerce ecosystems in China. Design/methodology/approach The open data of listed companies regarding the introduction of emerging topics on the transformation tendency of BMs in the post-COVID-19 business world is qualitatively analysed. The theoretical foundation is based on a critical review of the literature. Findings Three aspects of the co-evolution between knowledge management and business model transformation are introduced. These three aspects are as follows: knowledge integration helps with multi-system business integration and decision-making collaborations;knowledge sharing helps to enhance cognitive ability and network value based on businesses;and the creation of new knowledge helps enrich the knowledge base and promote the transformation of BMs. Research limitations/implications Solely attributing a firm's ability to cope with environmental uncertainties to its business model weakens the importance of its knowledge management. This study argues that the co-evolution between knowledge management and business model transformation also plays a key role in a firm's response to issues post-COVID-19. Originality/value This study calls for the development of a normative theory of co-evolution between knowledge management and business model transformation, implying uncharted territories of knowledge management based on interaction with business model designs in e-business ecosystems.

20.
Chinese Journal of General Practitioners ; 19(4):277-279, 2020.
Article in Chinese | Scopus | ID: covidwho-1143629

ABSTRACT

To prevent and control the epidemic of coronavirus disease 2019 (COVID-19), the community health service center should take the initiative to cooperate with sub-district office and police station to form a joint working team. Taking the advantages of professional expertise and using service contract system, the general practitioners can publicize the epidemic prevention knowledge and self-protection methods among community residents;and also take door-to-door inspection to make the decision of home isolation, centralized isolation, fever clinic visit or transfer to the designated hospital for observation and treatment. During the COVID-19 epidemic, we should give full play to the enthusiasm initiative of the community, general practitioners and residents to implement prevention and control measures and to ensure the health and safety of the people. © 2020 Chinese Medical Association

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